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KMID : 1149220090170020065
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.65 ~ p.72
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Acute Toxicity of Yukmijihwang-tang in ICR Mice
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Jeon Won-Kyung
Lee Jae-Hoon
Lee Ji-Hye
Kim Mi-Yeon
Ma Jin-Yeul
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Abstract
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Objectives : Yukmijihwang-tang (YJT) is known as a tonifying formula for reinforcement of yin deficiency conditions. The present study was carried out to investigate the potential acute toxicity of YJT in ICR male and female mice.
Methods : We investigated the acute toxicity about boiling water-extracted YJT. The test article was orally administered once by gavage to 20 male and 20 female mice at dose levels of 0 (control group), 1250, 2500 and 5000 ㎎/㎏ body weight. Mortalities, clinical findings, autopsy and body weight changes were monitored daily for the 14 days following the administration according to the Regulation of Korean Food and Drug Administration.
Results : We observed survival rates, general toxicity, change of body weight, and autopsy. Single oral administration of YJT with different dosages, no animals died of the test drug. Autopsy of animal revealed no abnormal gross finding. Therefore, LD50 value of YJT for ICR mice was more than 5000 ㎎/kg on oral route.
Conclusions : These results suggest that no toxic dose level of YJT in mice is considered to be more than 5000 ㎎/kg. Consequently, it was concluded that YJT have no effect on acute toxicity and side effect in ICR mice.
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KEYWORD
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Yukmijihwang-tang, Acute toxicity, LD50
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